CELEBRITY HEALTH

Christina Applegate shares emotional update after hospitalization in ongoing MS fight


Christina shared a statement on Instagram


© Getty
Jovita TrujilloSenior Writer
APRIL 20, 2026 4:07 PM EDT

Christina Applegate was seemingly forced to speak about her hospitalization after it made headlines last week. On April 16, it was reported by TMZ that she had been hospitalized since late March amid her ongoing battle with MS. 

Christina Applegate hospitalized amid MS battle, says report© Getty Images for Critics Choice
Christina Applegate was hospitalized for days to weeks

On Monday, the Married With Children star shared a photo on Instagram of a coffee cup sitting in her memoir You With the Sad Eyes. "Thank you for the outpouring of love and well wishes," she wrote. 

Christina Applegate gets candid about the ‘unimaginable’ pain of living with MS© Variety via Getty Images
She called the pain living with MS ‘unimaginable’

She went on to explain that this has become her new normal. "Health issues are a constant for me, but I’m a strong chick, and I’m getting stronger and better every day," the 54-year-old said. Good continued. The Anchroman star went on to explain that she was going to be taking a moment to focus on herself. "I’m taking a moment to focus on my health, but I’ll be back with more to say soon enough," she concluded. 

View post on Instagram
 

When news broke that she was hospitalised her team told USA TODAY, "She's had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast."

Christina Applegate has been open about her journey with multiple sclerosis since her 2021 diagnosis© Matt Winkelmeyer
Christina Applegate has been open about her journey with multiple sclerosis since her 2021 diagnosis

A source told Daily Mail, “Christina is a fighter, but her battle with MS has been treacherous. She has better days and really bad days; she doesn’t have great days."

Applegate has been candid about her health. In 2024, she opened up about her struggle with depression on her and Jamie-Lynn Sigler’s “Messy” podcast.

Christina Applegate attends the 26th Annual Screen Actors Guild Awards at The Shrine Auditorium on January 19, 2020 in Los Angeles© Gregg DeGuire
The actress has opened up about depression in the past

“I’m in a depression right now, which I don’t think I’ve felt that for years,” the actress shared. “Like a real, f**k-it-all depression where it’s kind of scaring me, too, a little bit because it feels really fatalistic,” she shared. 

“I’m trapped in, like, this darkness right now that I haven’t felt [in], like, I don’t even know how long, probably 20-something years.”

In a moment of “honesty,” Applegate said, as a result, she no longer enjoys living. “I don’t enjoy it. I don’t enjoy things anymore.”

What is Multiple Sclerosis? 

MS is a chronic disease that affects the central nervous system (brain, spinal cord, and nerves). It can lead to a wide range of symptoms, from mild (blurred vision, numbness, tingling) to severe (paralysis, vision loss, and mobility problems), per MedicalNewsToday.

According to the National Institute for Neurological Disorders and Stroke (NINDS), 250,000–350,000 people in the United States are living with MS. The National Multiple Sclerosis Society estimates the number could be closer to 1 million, per MedicalNewsToday.

If you or someone you know is struggling with depression, it’s important to seek help. Contact a mental health professional, talk to a trusted friend or family member, or contact a crisis hotline. You can text HOME to 741741 to connect with a Crisis Counselor.