Skip to main contentSkip to footer
Christina Applegate opens up about scary depression
  • España
  • Americas
  • México
  • Celebrities
    • Celebrity Couples
    • Celebrity Moms
    • Celebrity Kids
    • Celebrity Parents
    • Celebrity Homes
  • Entertainment
    • Music
    • Movies
    • TV
    • What to Watch
  • Royals
    • Kate Middleton
    • Meghan Markle
    • Prince Harry
    • Queen Letizia
    • Queen Maxima
    • Charlotte Casiraghi
    • Spanish Royals
    • British Royals
    • Monaco Royals
  • Beauty
    • Skincare
    • Makeup
    • Nails
    • Hair
    • Celebrity Beauty
  • Fashion
    • Celebrity Style
    • Royal Style
    • Fashion Trends
    • Street Style
    • Red Carpet
    • Runway
  • Lifestyle
    • Health and Wellness
    • Fitness and Workout
    • Leisure and Travel
    • Parenting
  • Food
    • Recipes
    • Healthy Food
    • Latin Cooking
    • Drinks and Cocktails
  • Americas
    • Celebridades
    • Entretenimiento
    • Realeza
    • Belleza
    • Moda
    • Lifestyle
    • Fotos
    • Latina Powerhouse
  • Latina Powerhouse
  • Photos
  • HOLA+
  • Celebrities
  • Entertainment
  • Royals
  • Beauty
  • Fashion
  • Lifestyle
  • Food
  • Americas
  • Latina Powerhouse
  • Photos
  • Hola+
  • Home
  • Celebrities

Christina Applegate opens up about scary, fatalistic depression amid battle with MS


She revealed her diagnoses in August 2021


US-ENTERTAINMENT-HWOF-APPLEGATE© GettyImages
Jovita TrujilloSenior Writer
JUNE 4, 2024 6:58 PM EDTJUN 4, 2024, 6:58 PM EDT

Christina Applegate is being very candid and open about her heartbreaking battle with Multiple Sclerosis (MS). The actress revealed her diagnosis back in August 2021, and three years later, she confessed to being in a deep depression that has left her feeling trapped.

US ENTERTAINMENT TV AWARDS EMMY SHOW© GettyImages
Christina Applegate received a standing ovation at the Emmys

Applegate opened up about her state of mind on her and Jamie-Lynn Sigler’s “MeSsy” podcast in an episode published Tuesday. But the episode was recorded after the “Dead to Me” star’s surprise appearance at the 2024 Emmy Awards in January, which she described as the “hardest” day of her life, saying she slept the next two days.

“I’m in a depression right now, which I don’t think I’ve felt that for years,” the 52-year-old actress shared. “Like a real, f**k-it-all depression where it’s kind of scaring me, too, a little bit because it feels really fatalistic,” she continued. “I’m trapped in, like, this darkness right now that I haven’t felt [in], like, I don’t even know how long, probably 20-something years.”

MS is a chronic disease that affects the central nervous system (brain, spinal cord, and nerves). It can lead to a wide range of symptoms that range from mild, (blurred vision, numbness, tingling) to severe, (paralysis, vision loss, and mobility problems), per MedicalNewsToday.

In a moment of “honesty” Applegate said as a result, she no longer enjoys living. “I don’t enjoy it. I don’t enjoy things anymore.”

CELEBRITY HEALTH:
  • Demi Lovato ‘felt defeated’ every time she had to ‘walk back into a treatment center’
  • Allison Holder reveals late Stephen Boss’ character ‘tWitch’ would ‘drain his energy’
  • Jennifer Lopez feels ‘relieved’ after canceling her tour: ‘She needs to take care of herself’

Sigler, who has battled MS for more than 20 years, acknowledged the pain, “It’s so hard to live in a disabled body. It is so hard. I will not take that away from you and I am right there with you,” but tried to encourage her.

“But what makes it harder is when you compare it to how it used to be....Once we get you to this place where we’re accepting that this is how it’s going to be, maybe forever...[MS] is not a reason enough for you to stop living because I sit here across from you, and you still make me laugh like nobody else can,” she told Applegate.

Although Applegate admitted to being scared of therapy, saying, “I’m so afraid for those floodgates to open and that I won’t be able to stop,” the episode ended with the “Samantha Who?” star promising to reach out to her therapist.

According to the National Institute for Neurological Disorders and Stroke (NINDS), 250,000–350,000 people in the United States are living with MS. The National Multiple Sclerosis Society estimates the number could be closer to 1 million, per MedicalNewsToday.

If you or someone you know is struggling with depression, it’s important to seek help. Contact a mental health professional, talk to a trusted friend or family member, or contact a crisis hotline. You can text HOME to 741741 to connect with a Crisis Counselor.

© ¡HOLA! Reproduction of this article and its photographs in whole or in part is prohibited, even when citing their source.

Other Topics
  • Christina Applegate
  • Mental Health
  • Celebrity Health
READ MORE
Paris Jackson’s six-year sobriety reflection is raw and inspiring: “I had to learn to live life on life’s terms”
Paris Jackson’s six-year sobriety reflection is raw and inspiring: “I had to learn to live life on life’s terms”By Maria Loreto
Kim Kardashian’s ex, Ray J, reveals doctors are trying to prolong his life
Kim Kardashian’s ex, Ray J, reveals doctors are trying to prolong his lifeBy Shirley Gomez
Bruce Willis knows nothing about his health diagnosis, his wife reveals
Bruce Willis knows nothing about his health diagnosis, his wife revealsBy Shirley Gomez
Chrissy Teigen says she's sober again and reveals how bad things got
Chrissy Teigen says she's sober again and reveals how bad things gotBy Jovita Trujillo
LATEST NEWS
Sabrina Carpenter gets pooped on by a dove named Tina at the Grammys - PETA reacts
Puerto Rican snacks and drinks to serve during the 2026 Super Bowl Halftime Show
Sydney Sweeney’s “Invisible Makeup”: the secret to perfect skin without foundation
Romantic 'Love Story' trailer shows the moment JFK Jr. and Carolyn Bessette first met
Valentine’s Day gift ideas for her 2026: The cute and flirty edit she’ll wear, use, and adore
Marius Borg, son of Crown Princess Mette-Marit, arrested again hours before trial
Grammys 2026 red carpet LIVE: Karol G, Justin and Hailey Bieber, Lady Gaga and more looks of the night
Natalia Boneta
© 2000-2026, HOLA S.L.
  • ¡HOLA! Spain
  • ¡HOLA! Americas
  • HELLO! UK
  • HELLO! US
  • HELLO! Canada
  • Privacy Policy
  • Legal Notice
  • Cookies Policy
  • Compliant channel
  • Contact