Tom Hanks and Rita Wilson
The first time these actors worked together was in 1981 in the series Bosom Buddies which is also where the attraction between them arose. Later they filmed the movie Volunteers, where they fell in love. They would eventually tie the knot, and yes, they're still going strong!
The public enjoyed seeing them alongside one another, so the directors and producers did not hesitate to bring them together in several more films, among them That Thing You Do! and Larry Crowne.