January arrives with fresh resolutions, and for many people, weight loss tops the list. In this context, medications like Ozempic and Mounjaro have surged in popularity. They’ve helped shift an important conversation: obesity is a health condition that requires real solutions, not miracle diets.
A growing body of research is raising alarms about weight regain after stopping GLP-1 medications such as Ozempic or Mounjaro. These drugs act on the brain to reduce hunger and increase satiety, leading to relatively rapid weight loss. But what happens when treatment ends?
We know these medications work. We also know that weight loss can happen quickly. However, studies now confirm what many patients experience: once the medication is stopped, much of the lost weight returns. This phenomenon, often called the “rebound effect,” raises a crucial question: Can it be prevented?
Why does weight return after GLP-1 treatments?
We spoke with Dr. Gontrand López-Nava, Director of the Endoscopic Bariatric Unit at HM Sanchinarro University Hospital in Spain, to understand the science behind this effect.
“These GLP-1 medications act directly on the brain, blocking appetite and satiety circuits at the level of the hypothalamus,” he explains. “But this blockage only works while the medication is being taken.”
Once treatment ends, the brain resumes its natural signaling. “Patients regain their appetite, feel less satiety, and often realize that their habits haven’t truly changed,” he says. “The body naturally seeks to recover the lost weight.”
This is why the risk of rebound is especially high when medication is not paired with long-term nutritional and lifestyle changes.
“We’re talking about regaining 80 to 90 percent of the weight that was lost, and the worst part isn’t just the weight itself, it’s that the cardiometabolic benefits disappear as well.”
How much weight is typically regained?
This is one of the most common questions among patients who have lost weight with Ozempic. According to Dr. López-Nava, the data are consistent.
“A meta-analysis published in The British Medical Journal shows that the amount of weight regained is almost the same as the amount lost,” he explains. “In practical terms, that means 80 to 90 percent of the weight often comes back.”
That rebound also erases improvements in blood sugar, cholesterol, and blood pressure, key health gains achieved during treatment.
Is changing habits the key to maintaining weight loss?
When asked whether lifestyle changes alone can preserve weight loss, Dr. López-Nava is clear: this is the real treatment for obesity.
“One side of the solution is helping patients control hunger, either through medication, endoscopic bariatric procedures, or other minimally invasive techniques,” he says. These procedures reduce stomach volume without traditional surgery. “It’s a standard endoscopy, we enter through the mouth, reduce the stomach size, and the patient leaves the same day, without pain or recovery time.”
But that’s only half of the equation.“The other half is bariatric psychology and nutrition,” he explains. “This is how patients truly change their lifestyle and relationship with food.”
Food should not become a channel for emotions such as anxiety, grief, celebration, or stress. “That’s why the psychological component is essential,” he adds. “It helps separate emotions from eating, creating consistent nutritional behavior regardless of what’s happening in life.”
Who can benefit from Bariatric Endoscopy?
In Dr. López-Nava’s program, bariatric endoscopy has become part of a comprehensive treatment model. “Any patient who needs to lose at least 12 kilograms benefits from what we call triple support,” he explains.
This includes:
- A stomach intervention to control hunger and satiety
- One to two years of bariatric psychological therapy
- Ongoing nutritional guidance to establish healthy eating patterns
“The combination of these three elements is what truly makes the treatment effective,” he emphasizes.
Who is a candidate? “Any person with overweight who is ready to commit, adhere to treatment, and genuinely wants to lose weight,” he says. “It’s not a miracle, but it’s a powerful tool.”
The Bigger Picture
The rise of Ozempic has opened the door to more comprehensive, long-term approaches to obesity. It has normalized asking for help and understanding excess weight as a health condition that requires time, follow-up, and a holistic strategy.
Medication can be a powerful starting point, but it is only one piece of the puzzle. Sustainable weight loss depends on adopting lasting habits, supported by medical, nutritional, and psychological care. And one message remains essential, these medications must always be used under medical supervision. When taken improperly, they can pose serious health risks.
Obesity is not a failure of willpower, it is a complex medical condition. Treating it successfully requires more than a prescription. It requires a plan for life.